Diclazuril, which is the a major member of the Benzeneactonitriles group; it is a safe
and potent coccidiocidal drug. Diclazuril is highly effective against Coccidia in chickens
and turkeys, the mode of action against the parasite stage is species-specific , thus in E.
maxima coccidiocidal activity is directed against the zygotes, and in E.brunetti against
the gametocytes, it is effective against the later schizont stages of E.acervulina and both
schizont and gametocytes of E.tenella. Amprolium which is a thiamine antagonist. The
anticoccidial effect of Amprolium is achieved by inhibiting the Eimeria spp. to uptake
thiamine. The thiamine requirement for Eimeria spp. is, compared to animals, relatively
high and therefore Amprolium will cause starvation of the parasite because of thiamine
deficiency. As this way is unique, Amprolium does not show cross-resistance with other
anticoccidial preparations.
